Is osteoporosis genetic?

Covenant HealthOur Town Health

Bone is living tissue that is broken down and replaced in our bodies continuous throughout life. Osteoporosis is a bone-thinning disease that causes bones to become weaker over time and more likely to break.

The disease can affect any bone, but the hip, spine and wrist are most often affected. Osteoporosis is often called a “silent disease” because people can’t feel their bones getting weaker.

Brad Davis

Brad Davis, DPT, OCS, MTC, is a physical therapist and physical therapy orthopedic specialist at Claiborne Medical Center, a member of Covenant Health. He serves as the clinical supervisor of the hospital’s rehabilitation programs.

Davis says, “Osteoporosis refers to bones that have become weak or brittle. Bones can become so brittle that a fall, bending over or even coughing can cause a bone break or fracture.”
He confirms that researchers don’t know the exact cause of osteoporosis, but many factors contribute to the disease. Men and women older than age 50 are at the greatest risk for bone-thinning and osteoporosis.

“Because of hormonal differences, women are four times more likely than men to develop osteoporosis,” Davis says. Race, weight, age and genetics also can be factors in developing the condition.

Symptoms of Osteoporosis

“Osteoporosis typically has no symptoms,” says Davis. “However, if the bone gets weak enough it can cause back pain from a broken or collapsed bone, loss of height, stooped posture and bones that break more easily.”

Many people don’t know they have osteoporosis or bone-thinning disease until they have advanced symptoms such as a broken hip or wrist, low back pain or a hunched back. Some may have pain in their bones and muscles, particularly in their back. Sometimes a collapsed vertebra may cause severe pain, decrease in height or spinal deformity.

The symptoms of osteoporosis may look like other bone disorders or health problems, so it’s important to talk with a healthcare provider for a diagnosis.

Osteoporosis vs. Osteopenia

Osteopenia describes a lower bone density than normal, but not low enough to be diagnosed as osteoporosis. While both conditions affect the strength and health of your bones, the difference between them is the level of bone damage. Osteopenia can be a precursor to developing osteoporosis if left untreated.

Is Osteoporosis Genetic?

“Osteoporosis can affect anyone, but females who are postmenopausal are at especially high risk because of hormones,” Davis says.

He explains there is a strong genetic component to osteoporosis, so knowing your hereditary traits and family history can help you understand your risk factors. Additional factors that can worsen osteoporosis include a sedentary lifestyle, poor dietary habits and frequent tobacco/alcohol use.

“The older we get, the higher risk we have for osteoporosis,” Davis says. “In addition to women being more affected, people of white or Asian descent are at a higher risk. Hormone levels are important, as low testosterone for men and low estrogen for women can hasten bone loss. Some medications for other health conditions also can increase your risk for osteoporosis.”

Who is at Risk for Osteoporosis?

Women are more likely to get osteoporosis than men. Factors that may put you at risk for osteoporosis include:

  • Age. Bones become less dense and weaker with age.
  • Race. White and Asian women are most at risk, but all races may get the disease.
  • Body weight. People who weigh less and have less muscle are more at risk for the condition.
  • Lifestyle factors. Lack of physical activity, caffeine, heavy alcohol use, smoking, low levels of dietary calcium, and vitamin D deficiency may all increase your risk.
  • Certain medicines. Some medicines may increase your risk, such as long-term use of corticosteroids, thyroid hormone replacement medications and immunosuppressant drugs.
  • Family history. Having a family history of bone disease may increase your risk.
  • Low bone mass (osteopenia) also puts you at a greater risk for osteoporosis.
  • Low estrogen is one of the main causes of bone loss in women during and after menopause. Women may lose up to 20 percent of their bone mass in the five to seven years after menopause.

Learn more:

How do I test for osteoporosis?

How do I prevent osteoporosis?

The biggest health risk associated with osteoporosis is a bone fracture – but there are steps you can take to keep the disease from worsening and causing breaks. Several types of physician specialists can treat osteoporosis including family practice doctors, rheumatologists and endocrinologists. Physical therapists can help design a safe and effective exercise routine to minimize bone loss and the effects of osteoporosis.

Covenant Health offers bone density DEXA screenings at multiple locations. Our imaging centers at Covenant Health Diagnostics-West and Covenant Health Diagnostics-South offer discounted cash payment rates for those who are not using insurance. A physician referral is needed. Call 865-374-4000 for information or view a list of our providers if you need a personal physician to help you achieve your best health.

Headquartered in Knoxville, Tennessee, Covenant Health is a community-owned, healthcare enterprise committed to providing the right care at the right time and place. Covenant Health is the area’s largest employer and has more than 11,000 caregivers, clinicians and dedicated employees and volunteers.


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